IL-4-Activated STAT-6 Inhibits IFN-γ-Induced CD40 Gene Expression in Macrophages/Microglia

IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia.

The antagonism between the cytokines IFN-gamma and IL-4 is well documented, but the mechanism by which IL-4 inhibits IFN-gamma-induced gene expression is not clearly understood. CD40 is a type I transmembrane protein that is critical for proper functioning of the immune system. We have previously shown that IFN-gamma is the most potent inducer of CD40 expression by macrophages and microglia. In...

Effects of 1,25-dihydroxyvitamin D3 on IL-17/IL-23 axis, IFN-γ and IL-4 expression in systemic lupus erythematosus induced mice model

Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

plasma levels of ifn-γ, il-4, il-6 and il-17 in hiv-positive patients with oral candidiasis

patients and methods in total, 98 samples in four groups (hiv-positive and hiv-negative persons with and without oc) were obtained from the oral cavities and cultured on sabouraud’s dextrose agar and chromagar. also blood samples were obtained to assess plasma level of ifn-γ, il-4, il-6 and il-17 using elisa technique. background cell-mediated immunity (cmi) by cd4 + th (t helper)-type cells is...

Suppressor of Cytokine Signaling-3 CD40 Gene Expression through Induction of IL-10 Inhibits Lipopolysaccharide-Induced

effects of 1,25-dihydroxyvitamin d3 on il-17/il-23 axis, ifn-γ and il-4 expression in systemic lupus erythematosus induced mice model

objective(s): systemic lupus erythematosus (sle) is a multi-factorial autoimmune disease which may be characterized by t lymphocytes dysfunctions. th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. in recent years, immunomodulatory effect of vitamin d3 has been noticed. in the present experiment, the effect of vitamin d3 on the expression of...